Furthermore, possible mediator variables, such as self-confidence, anger, mood state, and anxiety, have been shown to influence the hormonal stress to competition and were therefore included in the study. Performance in competitions and demanding work activities indicates that the concomitant measurement of hormonal and psychological parameters offers a unique possibility to achieve a more comprehensive evaluation of the stress responses of the practitioners 18,25. Coaches and applied practitioners should adopt "pre-competitive cognitive/coping strategies" to improve the psychological state that mediates the hormonal changes-competition/outcome relationship of their athletes in order to mitigate athletes’ stress. Striking combat sports are challenging, commonly stressing the endocrinological system based on a mixture of body-contact actions and physiological efforts. The presented data confirm that MMA is a high-intensity combat sport and the concentrations of biomarkers reflecting the degree of muscle cell damage (myoglobin, tumor necrosis factor, creatine kinase, and interleukin 6) remain high even 24 h after the competition. Two reviewers (MS and AP) conducted a methodological quality assessment on each included article using the modified Downs and Black scale , which is appropriate for nonrandomized control trials (NRCTs) and case–control study designs. The potentially relevant studies were screened for eligibility by two reviewers (MS and AP) by examining the titles, abstracts and full texts. Hormonal measurements methods using blood, urine or saliva samples were included in the present study. Indeed, this could be explained by the inconsistent effect of competition on the mediating variables or by the psychological state of practitioners prior to the competition. This controversy may be due to differences in age, gender, and the nature of the competition. It is known as the regulator hormone of immune function and has a catabolic effect on tissue. Cortisol is also a steroid hormone, secreted by the adrenal cortex via the hypothalamus-pituitary-adrenal (HPA) axis. Martial arts are highly popular among youth, and some studies have focused on how training affects hormone levels in younger populations. Intense training without adequate rest can lead to overtraining, which can actually cause testosterone levels to drop. The frequency of martial arts training can influence testosterone levels. This comprehensive exploration aims to uncover the effects of martial arts on testosterone levels, how various styles and training intensities contribute to these changes, and what implications they have for practitioners of all ages. The present review gathered studies about the hormonal response during official and simulation striking competitions, which are relevant for coaches to monitor training load and to facilitate the planning of specific training modalities. These findings highlight the catabolic hormonal responses that occurred, particularly during the second karate bout. Particularly, during two consecutive bouts, salivary cortisol (sC) increased progressively and significantly from pre-combat 1 to post-combat 1 and from pre-combat 1 to post-combat 2. Recently, Chaabène et al. showed that simulated karate competition could be considered as a challenging situation and a very-high intensity and stressful activity in male elite level karateka. The authors reported that both forms produced significant increases in glucose, T and catecholamine levels, without appreciable changes in insulin and C concentrations . Hormonal responses between pre- and post- taekwondo competition (mean ± SD or relative effect %). Hormonal responses between pre- and post-karate competition (mean ± SD or relative effect %). All studies were cross-sectional with pre- and post-combat hormonal analysis (Table 1, 2, 3). Fighters don’t take this hormone to get higher levels of aggression. Being able to train more than your opponent is a major edge in combat sports because it allows you to potentially develop a technical edge. Professional athletes work out at high-intensity levels and for several hours per day to maximize the benefits of their improved recovery. Ultimately, each method offers unique advantages and considerations, and fighters must carefully balance these to achieve peak performance while maintaining overall health and adhering to sports regulations. From the use of anabolic steroids (despite their legal and health risks) to natural methods like consistent quality sleep, diet, intense training, and stress management, fighters employ a range of techniques to boost their performance. The greatest increase of the bloodstream levels of noradrenaline concentration in karate could indicate a higher level of aggression in karate. Further studies can lead to practical conclusions regarding the psychological training of combat sport athletes. However, further studies are necessary to draw binding conclusions on the contribution of the emotional load of specific combat sport disciplines to the hormonal response. Another study showed that Polish wrestlers were more aggressive than karate fighters. On the other hand, the increase of the blood cortisol level following competition was similar in all groups analyzed. It seems likely that differences in the increase of noradrenaline level between the groups do not reflect the physical load of the exercise itself but rather the different emotional engagement/aggression levels in the respective disciplines.